Melanotan II
Synthetic Cyclic Melanocortin Receptor Agonist
Molecular Details
Overview
Melanotan II is a synthetic cyclic heptapeptide and non-selective agonist of melanocortin receptors (MC1R, MC3R, MC4R, and MC5R). Developed as a research tool to investigate melanocortin signaling pathways, it is an analog of the naturally occurring alpha-melanocyte-stimulating hormone (α-MSH). First studied in the 1990s, subsequent research has revealed activity across multiple physiological systems regulated by melanocortin signaling.
Published Research
Peripheral Nerve Regeneration
In vivo (rat) · 2003A rat sciatic nerve crush model demonstrated that melanotan-II enhanced recovery of sensory function following nerve injury and exhibited neuroprotective properties against cisplatin-induced toxic neuropathy.
Appetite & Energy Homeostasis
In vivo (mouse) · 2022Microinjection studies showed that melanotan-II significantly decreased appetitive responding and consumptive intake, contributing to understanding of melanocortin-4 receptor signaling in appetite regulation.
Social Bonding & Behavioral Effects
In vivo (comparative) · 2015Administration in prairie voles enhanced partner preference formation through MC3/MC4 receptor pathways, with species-specific selectivity demonstrating distinct melanocortin-dependent mechanisms in social behavior.
Thermogenic Response
In vivo (mouse) · 2020In PACAP-deficient mice, melanotan-II administration partially rescued impaired thermogenic capacity, indicating cross-pathway interactions between melanocortin and PACAP-dependent systems in thermoregulation.
Storage & Handling
Store lyophilized powder at –20°C to –80°C. Reconstituted solutions: refrigerate at 2–4°C for up to 7 days, or below –20°C for extended storage. Add carrier protein (0.1% HSA or BSA) for long-term reconstituted storage. Protect from moisture and light.
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For research purposes only. Not intended for human consumption. This profile summarizes published preclinical literature and does not constitute medical, clinical, or dosage guidance.